Thanks Ekim!! I didn't think of that.
Yes. I feel this is best solution over the smart object suggested, because the SmtObj doesn't truly flatten the pixel data to allow you to erase or use brush tool directly on. However, you can use the "Transform" to modify, and that might be all you need.
STEPS:
1) You can solo the layers you want to keep by putting in folder and "Alt+Click" the visibility eye.
2) Then use the "Render Video" from the panel option to export a PNG sequence with NO compression.
3) Now "Alt+Click" the visibility eye again to return to previous visibility settings.
4) Lastly, go to Layer > Video Layer > Import from File and select the first frame of the sequence and PS will bring it in as a video layer.
Now you can use brushes/eraser on the pixel data!!