I've tried uninstalling AE, running WINcleanCS3 and reinstalling AE but still can't get it to open. The rest of CS3 will open (Photoshop, Illustrator, Flash) but not After Effects. I have searched in c:/users/username/appdata/roaming/adobe/after effects/8.0 but can find no preferences.txt file. What happens when I try to open AE is I start the app and nothing happens. If I start it a second time the interface will open with no splash screen and I can view all menus but all items on the menu are grayed out and cannot be used. Then when I close it it gives me a 0:42 error. I'm stumped.
I also tried removing all the adobefnt.lst files, as I had read that som people were having an issue with that-still no luck. I tried starting it in safe mode (Vista) and it behaves the same way, bounces out on first start, then opens with no splash screen and all menus grayed out.