Here's my current configuration:
OWC Mercury Pro RAID drive (eSata/FW800/USB connections) - Configured as RAID 0
Two Hitachi DeskStar 7K3000 2TB drives.
Sonnet Echo ExpressCard/34 Thunderbolt adapter with Sonnet Tempo SATA ExpressCard/34 Controller Card (using eSata from drive to convert to Thunderbolt connection)
iMac mid-2011 machine with Thunderbolt ports, running most Adobe Premiere and After Effects