Hi, Michael. I did notice the files were PCM Big Endian.
The DP made the quicktimes from original Red files and sent them to me over the net. After I was unable to figure out the issue, I contacted him. He had tested them in Premiere Pro CC and they worked for him. I tested them in Avid MC7, Final Cut Pro 7 and Premeire Pro CS6 and all had static. He eventually tested in Final Cut Pro 7 and he had static as well. So, he re-exported and was able to remove the static by switching his audio format to AAC. When I expressed concern about this AAC audio being compressed, he tried PCM audio again and the static was gone. So, it's a mystery what caused the audio static. Perhaps he did switch to Little Endian without knowing it. What I found strange was that if I exported a quicktime with quicktime pro from the bad quicktime and brought that into my NLE, the static would disappear.
Film Editor, London UK
http://www.scottclementseditor.com