Try 4:2:2 instead. About the only situation where you'll see a difference in the picture quality of your shoot in HQ is if there is a lot of fast movement from frame to frame... sports for example. Otherwise it would look exactly the same and you only gain file size.
ProRes LT is a good option for most jobs quite frankly. It's broadcast quality, but not good for material with a lot of detail in it like outdoor shots of pine trees and grass etc...
Jerry
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