Chris, As long as the drive isn't physically damaged while its out of the system, it should come right back up when you reinstall it into the system. The only precaution I can think of would be if the drive you are removing is part of a RAID set. In that case you'll have to make sure that the drives are placed back into the exact same bays as there were previously. If its just a stand alone drive though, you shouldn't have any issues with removing it and replacing it at a later date.
Zero One Media Center
Apple Certified Hardware Technician