What are the best (Mp4) Media Encoder settings for playing HD through large monitors and Projection TV?

We produce video courses that are viewed in desktop arrangements, (15”-30”) or on large LED monitors (30”+ to 75”) or projected (10’ to 30’+)…. They have to be kept at high quality because of the text and graphic info. They are usually played directly off the hard drive or a USB-3 flash stick (never streamed).
Our masters that we export to Adobe Media Player are 1920X1280 or 1280X720 Cineform 10bit uncompressed files or exported directly off the Premiere CC 2014 timeline….. Our current setting for 1920X1080p is as below. Other than the high bit rate (too keep the picture from looking fuzzy or getting pixel blocking) is this the best setting layout? Can anyone recommend any improvements or suggestions? Please help! Thank you very much.

H.264
1920X1280
29.97p (Square Pixels)
NTSC
Profile= Main
Level 4.1
Rendered at Maximum Depth (Checked)
VBR, 2-Pass
Target Bit rate= 16Mbits
Maximum Bit rate= 16Mbits
Key Frame Distance= 72
Use Maximum Render Quality (Checked)
Audio= AAC, 4800Hz High Quality

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In the export panel under the Multiplexer tab check that stream compatibility is set to Standard. You might also consider increasing the target bitrate to 20-24 Mbps or higher; the 1280p equivalent to Blu-ray quality would be about 40-42 Mbps.