I'm in the process of researching my own DIY system. I must of read a couple of dozen postive responses regarding the ASUS P4C800E-Deluxe MoBo w/ the 875 Chipset. Haven't seen anything on your other choice. Personally, I'm going with the P4C. Keep in mind the P4C does not support PCI-E Cards. The market is obviously heading in this direction , but unless you're planning on HD Editing & Capture, no need to wait. Get a good graphics card and you should have a great machine.