I am running pIllusion on Vista Home Premium 64. Didnt do anything. Just install and run. No problem except if I mess to much with managing the library it will sooner or later crash, but I dont think it has anything to do with Vista.
Machine: Quad core 6600, nvidia 8800gts.
I couldn't get it to start when installing 3.01, might've just been that I needed to . But once I updated to 3.03 it works fine so far. This was on my laptop, will install on my new workstation soon and see what happens there.