How long are your finished sequences? 30 second spots? It really won't matter one way or the other. Longer sequences or programs for broadcast-yes it still matters.
Video doesn't run at a true 30fps but rather at 29.97/59.94 for broadcast. It's a technical throwback to the days when TV was converting to color broadcasting and it's still here.
Editing DF is pretty straight forward and transparent for the most part. It's had time to work most the bugs out of the process. Do not fear drop frame! There can be a few problem areas. Audio layback to tape or files used to be an issue when the timecode modes were mismatched. Mismatched audio sample rates/frame rates still cause a lot of issues.
Editing NDF into a DF sequence shouldn't be a problem. It's the same number of frames-no actual frames are dropped. Only the timecode changes.