Don't know about the Acrobat part, but as for the other:
Cleaner, Compressor, Squeeze, Compression Master, Flip4Mac, ProCoder, FFMPEG, etc., etc.
Lots of posts if you do a simple search of this and other forums. 2-5 gig to 200MB is easy.
[criis daw]"Anyone know he best way to compressa 2 GB movie (and a 5GB mov to around 200 MB for playback on a computer showing a presentation in acrobat ?"