I had to update my licensing on an iMac that I upgrade th OS X to El Captitan. All my production premium software updated fine except After Effects. It told me that AE CS6 would not work with ElCapitan.
From the Adobe blog (https://blogs.adobe.com/creativecloud/after-effects-ready-for-mac-os-x-v10-11-el-capitan/):
Note that After Effects CS6 requires the 11.0.4 update to work on any version of Mac OS X from 10.9 forward because of an incompatibility between newer versions of Mac OS X and a GPU library used by After Effects.
It is easier to destroy than to create.
More fun, too.