Hi James -
This topic has been discussed at length on the After Effects Forum, and it appears to be more tied to the projection device you plan on using, rather than the software - things to consider - is the projector taking your animation from a laptop or a DVD player? Here's a link to the discussion:
http://forums.creativecow.net/readpost/2/996847
Joe Bourke
Owner/Creative Director
Bourke Media
http://www.bourkemedia.com