The multiple GPUs in resolve only perform as fast as the slowest card in the set. The weakest link in the chain. Meaning that if you add a GTX580 in your box you'll only see as much of a performance improvement as you would having and additional 480. No faster.
That said better to be future proofing your purchase. Get a GTX580 3GB or a GTX680 4GB (if you're on, or want to be on 10.8) and then replace the 480's down the line for yet another boost in performance.
Or maybe get a pretty good deal on an aftermarket 480?
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