The MBox Mini has CoreAudio drivers on the Mac, so should work with any application that can use those, which is most of them. On the Windows side, you need to have the corresponding version of ProTools installed on the system for the drivers to work well with other applications. It should show up as an ASIO or WDM device. ASIO is better, of course. This should apply to the MBox2 Mini (squarish blue) and the newer MBox Mini (rounded dark grey). I don't remember there being a first-gen MBox Mini.
Once the drivers work, it's really up to you what software you use but these boxes are made for PT and should ship with ProTools Express at the minimum or in a bundle with ProTools.
This info is from a contact and I don't have personal experience of it myself, so your mileage may vary.
IHTH,
JC Boulay
Technical Director
Audio Z
Montreal, Canada
http://www.audioz.com
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