Thanks for the information in this thread everybody. I'm on 10.6.8, and if the GUI starts to slow down (particularly dragging clips around in the timeline) I now resize the window. In most cases I can make it about half-size for a minute, then go back to full-size and everything keeps working great!
This doesn't happen all that often to me, but it's good to know how to work around it when it does! (I'm perpetually afraid of upgrading the OS....)
Ben Unguren
Motion Graphics & Editing
http://www.mostlydocumentary.com