There was a thread on this same topic a while back and some pretty interesting methods were suggested, such as using a mirror to flip the image or even watching it upside down.
I usually use the method suggested by Glen, I burn a DVD or make a mixdown and watch it on my TV. It makes a big difference. Different room, different screen, a couch instead of a chair, no chance of stopping and fixing this or that little thing, you just sit and watch it as a whole.
Turning down the volume is also good. If it flows with no sound it'll be great with a soundtrack.
I also try to remember what my very first impression of the footage was. I sometimes develop a Stockholm Syndrome for bad footage. Weeks and weeks of trying to get it to work can make you think "it's not that bad, it kinda works…"
Then you see it on your couch and it doesn't really work. Then you remember you never really liked it. Time to get your scissors.
I find my very first impression is a very accurate measure.
This is the thread I was talking about.
http://forums.creativecow.net/thread/27/859575#859588