i've sent some pretty complex 2 video layer projects to color and back with no problem (latest versions of everything).
speed changes/dissolves/efx etc included.
just be aware of the limitations: you will not see dissolves/effects/superimposed video etc in color. also limitations of keyframes in color with speed changed media.
but if you are worried about it just bake.
http://www.postandbeam.tv
grade and finish @ post + beam