Re: Will this adapter/lens combination work?

It will most definitely "fit" with an adapter, but you will have focus issues.

The flange focus distance (distance from the mount's flange to the film/sensor) is much greater on a Canon than it is on a Leica M. This will make infinity focusing impossible; you will only be able to focus on very very close objects if at all. Unless you're doing macro photography exclusively, that lens will not be ideal for your Canon.