Instead of 2 units, you could check out avstumpfl's
SC Video dual Player which has 2 built-in compact flash players that can be synced to each other internally. Control can be via their SC Master units, probably the Lite version with a numbered keypad attached, or a touch panel controller (more $$$). I'm not familiar with the latter so you'd have to ask AvStumpfl re the 'how to'.
An alternative is Brightsign's
HD410 which seems to have interactive and sync features as well according to their blurb. There may be others.
Sometimes having 2 players in sync may be better than one dual player, just in case one fails, replacememnt for one is probably cheaper. But the major good point with compact flash players for 24/7 usage is that there are NO MOVING PARTS, so they are supposed to last, and last. And updating media is as simple as popping in new compact flash cards.
Thomas Leong