Maximum compatability between different computers and players

I don't normally worry about this much, but a client is asking for this and I'm not sure the best way. I usually just use 60 minute best quality and set the range between 5 and 7.5.

There is very little movement in my 15 minute video, all taking heads.

My source movies are 8 bit uncompressed, and I will most likely use Compression Master 3 to make the m2vs. It has 3 presets, 3, 5 and 7mbs single pass. Would the lowest one be the best to use?

I also have Squeeze 4.1, but I find it adds a lot of saturation to the m2vs and there arent any filters I could find, and Compressor 2 is awfully slow and then there's always QT. I could use a little advice on this, using DVDSP3.

Thanks in advance...